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Posterolaterale instabiliteit: Kniespecialist RPA Janssen is de topspecialist voor ernstige knieinstabiliteit in Zuid Nederland. Knieprothese: Weer een normaal leven! Ervaringen van patiënten op website RPA Janssen, kniespecialist Eindhoven.
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Brinkhof, S., Froeling, M., Janssen, R.P.A., Ito K., Klomp D.W.J. Can sodium MRI be used as a method for...

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Can sodium MRI be used as a method for mapping of cartilage stiffness?

Can sodium MRI be used as a method for mapping of cartilage stiffness?

Brinkhof, S., Froeling, M., Janssen, R.P.A., Ito K., Klomp D.W.J.
Magn Reson Mater Phy (2020). https://doi.org/10.1007/s10334-020-00893-x

Abstract

Objective

Sodium concentration is responsible for (at least part of) the stiffness of articular cartilage due to the osmotic pressure it generates. Therefore, we hypothesized that we could use sodium MRI to approximate the stiffness of cartilage to assess early cartilage degeneration.

Methods

Four human tibial plateaus were retrieved from patients undergoing total knee replacement (TKR), and their cartilage stiffness mapped with indentation testing, after which samples were scanned in a 7 T MRI to determine sodium concentration. The relation of biomechanical parameters to MRI sodium and glycosaminoglycan (GAG) concentration was explored by a linear mixed model.

Results

Weak correlations of GAG concentration with apparent peak modulus (p = 0.0057) and apparent equilibrium modulus (p = 0.0181) were observed and lack of correlation of GAG concentration versus MRI sodium concentration was observed. MRI sodium concentration was not correlated with apparent peak modulus, though a moderate correlation of MRI sodium concentration with permeability was shown (p = 0.0014).

Discussion and conclusion

Although there was correlation between GAG concentration and cartilage stiffness, this was not similar with sodium concentration as measured by MRI. Thus, if the correlation between MRI sodium imaging and GAG concentration could be resolved, this strategy for assessing cartilage functional quality still holds promise.

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RPA Janssen, MD PhD Prof
Orthopaedic Surgeon
Orthopaedic Associates Eindhoven Greater Area
Orthopedic Center Máxima
Máxima Medical Center (MMC)

Visiting adress MMC Eindhoven:
Ds. Th. Fliednerstraat 1
Ingang Zuid
5631 BM  Eindhoven
The Netherlands 
(outpatient clinic and surgery)

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De Run 4600
5504 DB  Veldhoven
The Netherlands
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Mail adress:
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5600 PD  Eindhoven
The Netherlands

Tel. 0031 (0)40 88 88 600
(Call center Orthopedie)

Fax: 0031 (0)40 88 85 938
www.rpajanssen.com 

Links:
KneeGuru
Orthopaedic Associates Eindhoven Greater Area
Máxima Medical Center
Eindhoven University of Technology
Fontys University of Applied Sciences
 

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